Anglo American has reported a pre-tax loss of $5.5bn (£3.8bn) for 2015 as sinking commodity prices hit the mining giant.
That was more than double the loss reported in 2014 as the company took charges of $3.8bn due to falls in commodity prices.
Chief executive Mark Cutifani said the global economy had presented the mining industry with "significant challenges".
Anglo plans to sell assets worth $3bn to $4bn to repair its finances.
The disposals will include Kumba Iron Ore, Africa's biggest miner of the steel-making ingredient.
"The company has initiated a review to consider options to exit from KIO at the appropriate time, including a potential spin-out," Anglo said.
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